Usage of Irbeloc Plus
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Treatment of essential hypertension, especially when monotherapy is inadequate
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Stage 2 hypertension or moderate-to-severe cases requiring dual therapy
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Suitable for:
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Patients with high cardiovascular risk
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Diabetics with early nephropathy
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Patients with left ventricular hypertrophy or metabolic syndrome
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First-line combination therapy in some cases, per updated international guidelines
Common Side Effects
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Amlodipine-related:
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Peripheral edema
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Headache
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Dizziness
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Flushing or palpitations
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Irbesartan-related:
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Fatigue
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Dizziness or light-headedness
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Hyperkalemia (rare)
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Gastrointestinal upset
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Note: Combination reduces amlodipine-induced edema due to RAAS modulation by Irbesartan.
Precautions
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Hepatic or renal impairment: Use cautiously and monitor function periodically
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Heart failure or post-MI: Monitor BP and renal parameters regularly
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Avoid in pregnancy – Category D
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Use cautiously in elderly and volume-depleted patients (risk of hypotension)
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Monitor serum potassium and creatinine in patients on RAAS-active agents
Drug Interactions
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Other antihypertensives: Additive hypotensive effects
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NSAIDs: May blunt antihypertensive effect and impair renal function
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Potassium supplements or potassium-sparing diuretics: Risk of hyperkalemia
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Simvastatin: Dose limitation recommended when combined with amlodipine
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Lithium: Risk of lithium toxicity increased with ARBs
Dosage and Administration
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Once daily, preferably at a fixed time
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Can be taken with or without food
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No need to adjust dose based on food intake
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Titrate if BP goals are not met, or use higher strengths if available
Storage
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Store in a cool, dry place, below 25°C
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Protect from light and moisture
Patient Counselling Tips
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Take the tablet daily, even when BP feels normal
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Inform about potential dizziness or swelling in feet
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Advise regular monitoring of BP, renal function, and electrolytes
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Instruct to avoid NSAIDs and potassium-rich foods/supplements unless advised
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Encourage healthy lifestyle: low-sodium diet, exercise, and smoking cessation
