Usage of Pitawin EZ
Pitawin EZ is indicated for:
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Primary hypercholesterolemia (familial or non-familial)
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Mixed dyslipidemia
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Patients with diabetes, metabolic syndrome, or statin intolerance
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High-risk or very high-risk cardiovascular patients requiring intensive lipid control
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As an adjunct to diet, lifestyle changes, and other lipid-lowering therapies
Mechanism of Action
🔹 Pitavastatin (2 mg)
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Inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis
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Increases LDL receptor expression → enhanced LDL clearance
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Also increases HDL-C, improves TG profile, and enhances insulin sensitivity
🔹 Ezetimibe (10 mg)
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Selectively blocks NPC1L1 transporter in the small intestine
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Inhibits dietary and biliary cholesterol absorption
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Complements statin effect by reducing cholesterol influx to liver
Together, they deliver synergistic LDL-C reduction via dual blockade:
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Synthesis + Absorption inhibition
Key Benefits
✅ ~55–60% LDL-C reduction (additive effect)
✅ Effective in statin-intolerant or low-dose statin candidates
✅ Raises HDL, improves atherogenic index (AI)
✅ Better TG control and insulin-friendly profile with Pitavastatin
✅ Reduced risk of hepatic enzyme elevation and myopathy vs. high-dose statins
Common Side Effects
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Headache, abdominal pain
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Mild muscle aches (rare)
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Flatulence, nausea
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Transient elevations in liver enzymes or CPK (infrequent)
Precautions
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Not for use in active liver disease or unexplained elevated liver enzymes
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Monitor LFTs and lipid profile periodically
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Avoid alcohol consumption during therapy
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Use with caution in elderly and patients with renal impairment
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Contraindicated in pregnancy and lactation
Drug Interactions
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Avoid concomitant use with strong CYP3A4 inhibitors (e.g., cyclosporine, gemfibrozil)
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May enhance effect of oral anticoagulants (e.g., warfarin)
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Safe with antidiabetics and antihypertensives
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Separate dosing from bile acid sequestrants (if used)
Dosage and Administration
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One tablet once daily, with or without food
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Administer at same time each day, preferably in the evening
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Dietary fat reduction enhances efficacy
Storage
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Store below 25°C, away from moisture and sunlight
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Keep out of reach of children
Patient Counseling Points
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Follow a low-fat, heart-healthy diet
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Report muscle pain, weakness, or jaundice
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Avoid grapefruit juice
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Do not stop therapy without consulting physician
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Regular lipid and liver monitoring is essential
