Irbekem MT

Irbekem MT

Composition:

  • Metoprolol Succinate IP 23.75 mg (Extended Release)

  • Irbesartan IP 150 mg
    Therapeutic Class:

  • Beta-Blocker + ARB (Angiotensin II Receptor Blocker)
    Schedule: Schedule H (Prescription Only)

Irbekem MT is a fixed-dose combination of Metoprolol Succinate, a cardioselective β1-blocker, and Irbesartan, an angiotensin II receptor blocker (ARB). This combination offers dual antihypertensive action by targeting both the sympathetic nervous system and the renin-angiotensin system, delivering effective blood pressure control, cardioprotection, and organ protection.

Usage of Irbekem MT

Irbekem MT is indicated for:

  • Mild to moderate essential hypertension

  • Patients with inadequate BP control on monotherapy

  • Hypertension with coexisting tachycardia or ischemic heart disease

  • Diabetic nephropathy and hypertensive nephropathy (Irbesartan role)

  • Heart failure (off-label in select patients) with preserved or reduced ejection fraction

Mechanism of Action

🔹 Metoprolol Succinate (23.75 mg, Extended Release)

  • β1-selective blocker → reduces heart rate, myocardial contractility

  • Lowers cardiac output and sympathetic drive

  • Provides anti-anginal and anti-arrhythmic effects

  • Once-daily sustained action ensures smoother BP and HR control

🔹 Irbesartan (150 mg)

  • Blocks AT1 receptors, inhibiting vasoconstriction and aldosterone secretion

  • Reduces vascular resistance, sodium retention, and proteinuria

  • Effective in diabetic nephropathy and LVH regression

Key Benefits

✅ Dual pathway BP control: neurohormonal + vascular
✅ Provides heart rate regulation — beneficial in patients with palpitations or CAD
✅ Improves end-organ protection (kidney, heart, vessels)
✅ Lower incidence of cough or angioedema (vs. ACE inhibitors)
✅ Once-daily dosing improves compliance

Common Side Effects

  • Dizziness or fatigue (initial days)

  • Bradycardia (dose-dependent)

  • Hypotension

  • GI upset or nausea

  • Rare: Erectile dysfunction, cold extremities, sleep disturbances

Precautions

  • Avoid abrupt withdrawal of metoprolol — may cause rebound tachycardia or hypertension

  • Use with caution in patients with:

    • Bradycardia or AV block

    • Asthma or COPD (beta-blocker caution)

    • Renal artery stenosis or severe renal dysfunction

  • Regular monitoring of BP, HR, and renal function is advised

  • Not for use in pregnancy or lactation

Drug Interactions

  • Additive hypotensive effects with diuretics or other antihypertensives

  • May interact with NSAIDs (reduced efficacy)

  • Caution with calcium channel blockers (risk of bradycardia or AV block)

  • Avoid with lithium (Irbesartan may increase lithium levels)

Dosage and Administration

  • One tablet once daily, preferably in the morning

  • Can be taken with or without food

  • Titrate based on clinical response and tolerability

  • Do not crush or chew the tablet (extended-release)

Storage

  • Store below 25°C, protected from light and moisture

  • Keep out of reach of children

Patient Counseling Points

  • Take regularly at the same time every day

  • Do not stop abruptly without medical advice

  • Report symptoms like dizziness, slow heartbeat, or swelling

  • Monitor BP and pulse regularly at home if possible

  • Follow dietary salt restriction and lifestyle modifications for best outcomes

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