Usage of Azokem 8
Azokem 8 is indicated for:
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Essential hypertension (mild to moderate)
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Isolated systolic hypertension
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Hypertensive patients with coexisting tachycardia
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May also be used in cases of left ventricular hypertrophy (LVH) or elderly hypertension
Mechanism of Action
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Blocks L-type calcium channels in vascular smooth muscle
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Causes vasodilation → reduces systemic vascular resistance
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Does not stimulate the sympathetic nervous system, hence minimal reflex tachycardia
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Also exhibits antioxidant properties and reduces sympathetic tone
Key Benefits
✅ 24-hour BP control with once-daily dosing
✅ Minimal pedal edema vs. amlodipine
✅ No reflex tachycardia
✅ Organ-protective (kidney, heart)
✅ Safe in elderly hypertensives
Common Side Effects
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Mild headache or dizziness
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Flushing (rare)
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Palpitations (very rare)
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Fatigue
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Edema (significantly lower incidence compared to amlodipine)
Precautions
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Not recommended in pregnancy or lactation
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Use with caution in hepatic impairment
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Avoid abrupt discontinuation
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Monitor BP regularly, especially in elderly or dehydrated patients
Drug Interactions
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Enhanced effect when used with other antihypertensives
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Use cautiously with beta-blockers or diuretics
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Grapefruit juice may increase azelnidipine levels (avoid concurrent intake)
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Minimal interaction with CYP enzymes
Dosage and Administration
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Usual dose: 8 mg once daily
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Dose may be adjusted (4 mg to 16 mg) based on patient response
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Take after breakfast; avoid high-fat meals to prevent enhanced absorption
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Onset of action: slow (1–2 hours); ideal for smooth BP control
Storage
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Store below 30°C
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Protect from light and moisture
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Keep out of reach of children
Patient Counseling Points
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Take the medicine at same time daily, preferably in the morning
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Avoid sudden posture changes to prevent dizziness
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Do not consume grapefruit juice during therapy
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Report persistent swelling of ankles or unusual fatigue
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Follow prescribed diet and lifestyle measures for hypertension
