Azokem Plus
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Azokem Plus

Composition:

  • Azelnidipine IP 8 mg

  • Olmesartan Medoxomil IP 40 mg
    Therapeutic Class:

  • Calcium Channel Blocker (CCB) + Angiotensin II Receptor Blocker (ARB)
    Schedule: Schedule H (Prescription Only)

Azokem Plus is a dual antihypertensive therapy that combines the vasodilatory effect of Azelnidipine, a third-generation CCB, with the RAAS-suppressing action of Olmesartan, a potent ARB. This combination provides complementary and synergistic blood pressure control with excellent cardiovascular and renal safety.

It is especially effective in moderate to severe hypertension, or in patients uncontrolled on monotherapy.

 

Usage of Azokem Plus

Azokem Plus is indicated for:

  • Essential hypertension not controlled by monotherapy

  • Stage 2 hypertension requiring combination therapy

  • High-risk hypertensive patients (e.g., with diabetes, LVH, metabolic syndrome)

  • Suitable for younger, middle-aged, or elderly hypertensives

  • May also help in target organ protection (heart, kidneys, vessels)

Mechanism of Action

🔹 Azelnidipine 8 mg (CCB)

  • Inhibits L-type calcium channels → vasodilation of arterioles

  • Long-acting with minimal reflex tachycardia and edema

  • Also exhibits anti-oxidative and anti-sympathetic effects

🔹 Olmesartan Medoxomil 40 mg (ARB)

  • Blocks angiotensin II AT1 receptors → inhibits vasoconstriction & aldosterone secretion

  • Reduces peripheral vascular resistance, cardiac afterload, and BP

  • Offers renoprotective and cardioprotective effects

Together, they deliver synergistic BP reduction, better vascular compliance, and reduce risk of end-organ damage.

Key Benefits

✅ Powerful 24-hour BP control
✅ Minimal side effects – no reflex tachycardia or significant pedal edema
✅ Improves arterial stiffness and vascular tone
✅ Renal and cardiovascular protection
✅ Once-daily dose enhances adherence

Common Side Effects

  • Mild dizziness, headache

  • Rare ankle edema (much lower vs. amlodipine combos)

  • Fatigue or mild GI upset

  • Rare: Hypotension, elevated potassium (Olmesartan-related)

Precautions

  • Avoid in pregnancy (Category D) and lactation

  • Use with caution in renal artery stenosis, severe renal impairment, or volume-depleted patients

  • Monitor serum creatinine and potassium periodically

  • Avoid sudden withdrawal, especially in long-term users

Drug Interactions

  • Additive effect with other antihypertensives

  • Potassium-sparing diuretics, ACE inhibitors, or K+ supplements → risk of hyperkalemia

  • NSAIDs may reduce antihypertensive efficacy

  • Grapefruit juice may increase azelnidipine levels—avoid during treatment

Dosage and Administration

  • One tablet once daily, preferably in the morning after breakfast

  • Swallow whole with water; do not crush or split

  • Dosage titration should be based on BP monitoring and physician discretion

Storage

  • Store below 25°C, in a dry place away from direct sunlight

  • Keep out of reach of children

Patient Counseling Points

  • Maintain a low-salt, heart-healthy diet

  • Take at the same time each day

  • Avoid sudden posture changes (orthostatic hypotension risk)

  • Report swelling of legs, dizziness, or muscle cramps

  • Routine BP, renal function, and electrolyte monitoring recommended

 

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