Usage of Doxy Bro 500
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Chronic Obstructive Pulmonary Disease (COPD)
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Bronchial asthma
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Chronic bronchitis with mucus hypersecretion
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Asthmatic bronchitis
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Smoker’s cough and mucus retention syndromes
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As an add-on to inhaled corticosteroids and beta-agonists
Common Side Effects
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Nausea, vomiting
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Abdominal discomfort
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Headache
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Drowsiness or restlessness (less common with doxofylline than with theophylline)
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Rare: Allergic skin reactions or dry mouth
Note: Doxofylline has a better safety profile than theophylline with significantly reduced cardiac and CNS stimulation.
Precautions
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Hepatic or renal impairment: Use with caution and monitor closely
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Avoid in patients with peptic ulcer disease
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Use cautiously in patients with a history of seizures
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Not recommended during pregnancy and lactation unless clearly needed
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Caution in elderly patients and those with cardiac arrhythmias
Drug Interactions
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Beta-agonists & corticosteroids: Additive bronchodilation (beneficial)
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Antibiotics like erythromycin, ciprofloxacin: May affect metabolism
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CNS stimulants: May increase risk of restlessness
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Alcohol: May increase sedative effects
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Doxofylline does not significantly interact with CYP1A2—safer in polypharmacy
Dosage and Administration
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One tablet twice daily, or as prescribed by the physician
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Preferably taken after meals to reduce GI irritation
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Adequate hydration improves mucolytic effectiveness
Storage
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Store in a cool, dry place below 25°C
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Protect from moisture and sunlight
Patient Counselling Tips
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Take the medicine as prescribed, even if symptoms improve
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Do not crush or chew the tablet
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Maintain adequate fluid intake to help mucus thinning
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Report symptoms like palpitations, tremors, or persistent headache
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Do not use as a substitute for rescue inhalers in acute asthma attacks
