Flupikem T4
Flupikem T4 - Image 2
Flupikem T4 - Image 3
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Flupikem T4

Composition:

  • Flupirtine Maleate 100 mg

  • Thiocolchicoside IP 4 mg
    Therapeutic Class:

  • Centrally Acting Analgesic & Muscle Relaxant Combination
    Schedule: Schedule H (Prescription Only)

Flupikem T4 is a combination of Flupirtine, a centrally acting non-opioid analgesic, and Thiocolchicoside, a muscle relaxant with anti-inflammatory properties. This formulation provides dual action relief by targeting both neuropathic pain and muscular spasms, making it suitable for acute and chronic musculoskeletal conditions.

Usage of Flupikem T4

Indicated in the management of:

  • Acute and chronic low back pain

  • Cervical and lumbar spondylosis

  • Muscle spasms associated with orthopedic trauma

  • Fibromyalgia and myofascial pain

  • Post-surgical musculoskeletal pain

  • Pain with underlying neural or spastic component

Mechanism of Action

Flupirtine:

  • Acts as a selective neuronal potassium channel opener (SNEPCO)

  • Exhibits analgesic and muscle-relaxing properties via NMDA receptor modulation

  • No sedation or respiratory depression like opioids

Thiocolchicoside:

  • A GABA-A receptor agonist that provides muscle relaxation

  • Reduces inflammatory pain and muscle contractures

  • Acts both centrally and at the spinal level

Together, the combination:

  • Reduces neurogenic pain and muscle hyperactivity

  • Improves mobility, comfort, and recovery

Key Benefits

✅ Dual action on pain and muscle spasm
✅ Effective in both neuropathic and nociceptive pain
✅ Non-opioid and non-NSAID – minimal GI or renal side effects
✅ Improves range of motion and physical function
✅ Better patient compliance due to central analgesia without sedation

Common Side Effects

  • Drowsiness

  • Dizziness

  • Nausea

  • Abdominal discomfort

  • Diarrhea (rare with thiocolchicoside)

Most side effects are mild and resolve with continued use or dose adjustment.

Precautions

  • Flupirtine may cause liver enzyme elevation — avoid long-term use

  • Limit use to <14 days (as per regulatory guidance in many countries)

  • Avoid in patients with hepatic impairment

  • Monitor LFTs if therapy exceeds 1 week

  • Thiocolchicoside is contraindicated in pregnancy, lactation, and epileptic patients

  • Use caution in elderly patients

Drug Interactions

  • Avoid with other CNS depressants (alcohol, opioids, sedatives)

  • Flupirtine may potentiate anticoagulants

  • Avoid with hepatotoxic drugs (e.g., isoniazid, methotrexate)

Dosage and Administration

  • 1 tablet twice daily, after meals

  • Do not exceed prescribed duration

  • Not recommended for children below 18 years

Storage

  • Store below 25°C

  • Protect from moisture and sunlight

  • Keep out of reach of children

Patient Counseling Points

  • Do not drive or operate heavy machinery if feeling drowsy

  • Avoid alcohol during treatment

  • Report symptoms like jaundice, fatigue, or dark urine (signs of liver dysfunction)

  • Take with food to minimize gastric upset

  • Adhere to short-term use only, as prescribed

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