Flusolip 40
Flusolip 40 - Image 2
Flusolip 40 - Image 3
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Flusolip 40

Composition:

  • Fluvastatin Sodium 40 mg
    Therapeutic Class:

  • HMG-CoA Reductase Inhibitor (Statin)
    Schedule: Schedule H (Prescription Drug)

Flusolip 40 is a lipid-lowering agent containing Fluvastatin, a statin that effectively reduces elevated LDL cholesterol, total cholesterol, and triglycerides, while modestly increasing HDL levels. It is widely prescribed for primary and secondary prevention of cardiovascular events, especially in patients with mild to moderate hyperlipidemia or statin intolerance.

Usage of Flusolip 40

Indicated for:

  • Primary hypercholesterolemia (Type IIa)

  • Mixed dyslipidemia (Type IIb)

  • Familial and non-familial hyperlipidemia

  • Primary and secondary prevention of coronary heart disease (CHD)

  • Post-myocardial infarction lipid control

  • Patients intolerant to higher-potency statins

Mechanism of Action

Fluvastatin is a competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.

  • Reduces hepatic cholesterol synthesis

  • Increases LDL receptor expression, enhancing LDL clearance

  • Also shows anti-inflammatory and plaque-stabilizing effects

Key Benefits

✅ Effective LDL-C reduction (~25–30%)
✅ Safe for patients with mild hepatic or renal impairment
✅ Shorter half-life – minimal accumulation
✅ Well tolerated in statin-sensitive patients
✅ Can be used in diabetic or elderly populations

Common Side Effects

  • Headache

  • Fatigue

  • Dyspepsia

  • Mild myalgia

  • Elevated liver enzymes (infrequent)

Myopathy and rhabdomyolysis are rare but possible with statins; monitor when used with interacting drugs.

Precautions

  • Monitor liver enzymes before and during therapy

  • Use caution in patients with a history of liver disease

  • Avoid in active liver disease or persistent unexplained LFT elevation

  • Caution in hypothyroidism, renal dysfunction, or elderly patients

  • Avoid alcohol and high-fat diets for optimal results

Drug Interactions

  • Avoid concurrent use with cyclosporine, fibrates, or azole antifungals

  • Risk of myopathy increases with niacin or macrolide antibiotics

  • Take 2 hours apart from bile acid sequestrants (e.g., cholestyramine)

Dosage and Administration

  • 1 tablet once daily, preferably in the evening (when cholesterol synthesis peaks)

  • Dose adjustment may be needed after 4 weeks based on lipid response

  • Can be used in combination with ezetimibe or fenofibrate under monitoring

Storage

  • Store below 25°C in a dry place

  • Protect from light and moisture

  • Keep out of reach of children

Patient Counseling Points

  • Continue low-fat, low-cholesterol diet during therapy

  • Report muscle pain, tenderness, or weakness

  • Avoid alcohol and grapefruit juice

  • Regularly monitor lipid profile and liver enzymes

  • Not recommended during pregnancy or breastfeeding

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