Usage of Leomed
Indicated for the management of:
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Functional dyspepsia
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Gastroesophageal reflux disease (GERD)
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Chronic gastritis with reflux symptoms
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Bloating, epigastric fullness, and nausea
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Delayed gastric emptying
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Non-ulcer dyspepsia
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As adjuvant in irritable bowel syndrome (IBS-D) with upper GI symptoms
Mechanism of Action
🧠Levosulpiride (75 mg)
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A substituted benzamide and selective dopamine D2 antagonist
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Enhances gastric and intestinal motility by promoting acetylcholine release in the enteric nervous system
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Improves symptoms of gastroparesis, bloating, and epigastric distress
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Also possesses mild anxiolytic and antidepressant effects via central D2 receptor blockade
🧪 Magnesium Hydroxide (as trihydrate, 40 mg)
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Acts as a rapid-acting antacid
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Neutralizes excess gastric acid, offering quick relief from heartburn and acidity
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Also has a mild laxative effect which helps counteract gastric stasis
Common Side Effects
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Abdominal cramps or bloating
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Diarrhea (due to magnesium component)
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Mild sedation or fatigue (rare, due to levosulpiride)
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Galactorrhea or menstrual changes with prolonged use (levosulpiride)
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Dry mouth or metallic taste
Precautions
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Contraindicated in patients with GI hemorrhage, perforation, or obstruction
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Use cautiously in renal impairment (due to magnesium retention risk)
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Avoid in pregnant or lactating women unless absolutely necessary
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Long-term use may lead to hypermagnesemia or extrapyramidal symptoms
Drug Interactions
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Levosulpiride:
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May enhance the effects of CNS depressants
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Use cautiously with antipsychotics (dopaminergic interactions)
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Magnesium Hydroxide:
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May reduce absorption of tetracyclines, fluoroquinolones, iron, and digoxin
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Give at least 2 hours gap with other oral medications
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Dosage and Administration
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Usual adult dose: One tablet twice daily, 30 minutes before meals
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Duration: Based on indication, typically 2–4 weeks for functional dyspepsia
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Do not crush or chew; swallow with water
Storage
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Store below 25°C in a dry place
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Protect from moisture and light
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Keep out of reach of children
Patient Counseling Points
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Take on an empty stomach (preferably before meals)
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May take a few days to show full benefit in functional GI disorders
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Avoid taking antacids or dairy within 1 hour of this medicine
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Report any signs of menstrual changes, breast tenderness, or excessive fatigue if on long-term therapy
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Maintain hydration if mild diarrhea occurs
