Nutam Plus
Nutam Plus - Image 2
Nutam Plus - Image 3
, , ,

Nutam Plus

Contains:

  • Gabapentin IP 400 mg

  • Nortriptyline IP 10 mg
    Therapeutic Class: Antineuropathic & CNS Modulator
    Schedule: Schedule H (Prescription Drug)

Nutam Plus is a synergistic combination of two centrally acting agents:

  • Gabapentin: A structural analogue of GABA that binds to α2δ subunits of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters like glutamate and substance P.

  • Nortriptyline: A tricyclic antidepressant (TCA) that blocks the reuptake of norepinephrine and serotonin, enhancing descending pain inhibition pathways.

Together, they offer potent, dual-mechanism control of neuropathic pain, addressing both nerve hypersensitivity and central pain perception, while improving mood and sleep disturbances associated with chronic pain.

Usage of Nutam Plus

  • Diabetic peripheral neuropathy

  • Post-herpetic neuralgia

  • Trigeminal neuralgia

  • Cervical/lumbar radiculopathy

  • Fibromyalgia

  • Chronic low back pain with neuropathic features

  • Neuropathy secondary to chemotherapy or HIV

  • Central sensitization disorders

Common Side Effects

  • Gabapentin-related: Dizziness, drowsiness, fatigue, ataxia, weight gain

  • Nortriptyline-related: Dry mouth, constipation, orthostatic hypotension, blurred vision

  • Others: Mild cognitive slowing, edema, mood alterations (rare)

Most side effects are transient and dose-related, and can be minimized by starting low and titrating gradually.

Precautions

  • Use caution in renal impairment – Gabapentin is renally excreted

  • Caution in cardiac disorders, especially in patients at risk of arrhythmia (due to nortriptyline)

  • Avoid abrupt discontinuation – risk of withdrawal symptoms and rebound pain

  • Caution in elderly patients due to risk of sedation and falls

  • Not advised in pregnancy and lactation unless clearly indicated

  • Monitor for suicidal ideation, especially during treatment initiation

Drug Interactions

  • Alcohol and CNS depressants: Additive sedative effects

  • MAO inhibitors: Contraindicated with nortriptyline

  • SSRIs/SNRIs: Risk of serotonin syndrome (rare, but caution advised)

  • Anticholinergics: Additive side effects with nortriptyline (dry mouth, constipation)

  • Opioids: Risk of enhanced CNS depression

Dosage and Administration

  • Typically once or twice daily, based on physician assessment

  • Usually taken after food to reduce gastric irritation

  • Initiate at night to reduce daytime sedation

  • Titrate slowly based on clinical response and tolerability

Storage

  • Store below 25°C, in a dry place away from light

  • Keep out of reach of children

Patient Counselling Tips

  • May cause drowsiness or dizziness—avoid alcohol and driving

  • Inform the doctor of any mood changes, palpitations, or swelling

  • Maintain a consistent dosing schedule

  • Do not stop suddenly—tapering required

  • Inform about delayed onset—clinical effect usually seen within 1–2 weeks

  • Emphasize adherence even if pain improves, as neuropathic pain tends to recur with discontinuation

Related products

Review My Order

0

Subtotal

Taxes & shipping calculated at checkout

Checkout