Usage of Rocard-F 77
Rocard-F 77 is indicated in the treatment of:
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Mixed dyslipidemia (elevated LDL-C + high TG + low HDL-C)
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Severe hypertriglyceridemia
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Atherogenic dyslipidemia in type 2 diabetes or metabolic syndrome
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Residual cardiovascular risk in statin monotherapy non-responders
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Cardiovascular prevention in high-risk patients (secondary prevention)
Mechanism of Action
🩺 Rosuvastatin (10 mg)
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Inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis
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Lowers LDL-C, total cholesterol, and ApoB
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Modestly increases HDL-C
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Has anti-inflammatory and plaque-stabilizing properties
🧬 Fenofibrate (67.5 mg)
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Activates PPAR-α (peroxisome proliferator-activated receptor alpha)
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Enhances lipolysis and clearance of TG-rich particles
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Significantly lowers triglycerides and VLDL, increases HDL-C
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Improves insulin sensitivity and endothelial function
Common Side Effects
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Myalgia, muscle cramps
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Headache or dizziness
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Elevated liver enzymes (transaminases)
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GI disturbances (nausea, abdominal pain)
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Rare: Myopathy, rhabdomyolysis (in predisposed individuals)
Precautions
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Avoid in active liver disease or persistent elevations of hepatic transaminases
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Use cautiously in renal impairment; monitor renal function
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Avoid in patients with gallbladder disease
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Monitor CPK levels if muscle pain or weakness occurs
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Avoid excessive alcohol intake
Drug Interactions
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Statins + Fibrates: Risk of myopathy increases—especially with gemfibrozil (fenofibrate is safer)
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Cyclosporine: Increases rosuvastatin exposure
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Warfarin: Fenofibrate may potentiate anticoagulant effect—monitor INR
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Avoid concurrent use with other hepatotoxic or myotoxic agents
Dosage and Administration
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One tablet once daily, preferably in the evening, with or without food
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Monitor lipid levels, liver enzymes, and renal function periodically
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Ensure baseline CPK and LFTs before initiation
Storage
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Store in a cool, dry place below 25°C
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Protect from light and moisture
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Keep out of reach of children
Patient Counseling Points
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Report unexplained muscle pain, tenderness, or weakness
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Adhere to low-fat, heart-healthy diet alongside therapy
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Avoid grapefruit juice and alcohol overuse
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Periodic blood tests are needed to monitor safety and efficacy
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Safe use during pregnancy and lactation is not established; contraindicated
