Topmed 200
Topmed 200 - Image 2
Topmed 200 - Image 3
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Topmed 200

Composition:

  • Oxaceprol 200 mg
    Therapeutic Class:

  • Anti-inflammatory (Non-NSAID) / Disease-Modifying Osteoarthritis Drug (DMOAD)
    Schedule: Schedule H

Topmed 200 is a unique non-steroidal anti-inflammatory agent (non-NSAID) that contains Oxaceprol, an amino acid derivative that exerts potent anti-inflammatory and cartilage-protective effects without inhibiting cyclooxygenase (COX) enzymes. It is widely used in the treatment of osteoarthritis and other chronic inflammatory joint conditions, especially in patients who are intolerant to NSAIDs.

Usage of Topmed 200

Indicated for the management of:

  • Osteoarthritis (knee, hip, and other joints)

  • Degenerative joint diseases

  • Chronic inflammatory conditions of joints and soft tissues

  • Alternative to NSAIDs in patients with gastric sensitivity or renal risks

Mechanism of Action

  • Oxaceprol modulates leukocyte-endothelium interactions and inhibits migration of polymorphonuclear leukocytes (PMNs) to inflamed tissue

  • Reduces release of pro-inflammatory cytokines like IL-1β and TNF-α

  • Does not inhibit COX-1 or COX-2, thus spares gastric mucosa and kidney function

  • Slows cartilage degradation by modulating inflammation at the cellular level

Key Benefits

✅ Safe alternative to NSAIDs in long-term therapy
✅ No gastric irritation or ulcerogenic effects
✅ Preserves renal and cardiovascular safety
✅ Suitable for elderly patients and those on polypharmacy
✅ Disease-modifying potential in osteoarthritis with regular use

Common Side Effects

  • Mild gastrointestinal discomfort (rare)

  • Skin rash or allergic reactions (infrequent)

  • No known risk of gastric ulceration or bleeding

  • No nephrotoxicity or hepatotoxicity at therapeutic doses

Precautions

  • Not recommended in pregnancy or lactation due to limited data

  • Use cautiously in patients with known hypersensitivity to oxaceprol or amino acid derivatives

  • Not intended for acute pain relief – works best for long-term inflammation control

Drug Interactions

  • No major drug-drug interactions reported

  • Can be safely combined with paracetamol, NSAIDs (short term), or glucosamine/chondroitin supplements

  • May enhance effects of other disease-modifying therapies

Dosage and Administration

  • 1 tablet (200 mg) twice daily after meals

  • Duration of therapy: Minimum 4–6 weeks for noticeable clinical benefits

  • Can be continued long-term under medical supervision

Storage

  • Store at room temperature (<25°C)

  • Protect from moisture and direct sunlight

  • Keep out of reach of children

Patient Counseling Points

  • Inform patients that symptom relief may take 2–4 weeks

  • Encourage joint-friendly exercises and weight control

  • No need to stop for minor procedures or blood tests

  • Safe for long-term use under medical guidance

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